Sign Out
Pharmacology: Ketoprofen, in a suitable vehicle, reaches by transcutaneous route the inflammation site, allowing local treatment of pain of joints, tendons, ligaments and muscles.
Following oral administration of a single dose within 2 hours maximum blood concentrations are reached.
Plasma half-life of ketoprofen varies from 1 hour to 3 hours: binding to plasma proteins is 60-90%. Elimination occurs mainly by urinary route, in glucuronoconjugated form: approximately 90% of the administrated dose is excreted within 24 hours.
Conversely the absorption by cutaneous route is very low. In fact the application of 50-150 mg of ketoprofen by percutaneous route determines plasma levels of the active ingredient equal to 0.08-0.15 μg/ml about 5-8 hours after the application.
